Inside the complex, there is a museum dedicated mainly to the acquisition of Louisiana and the Lewis and Clark Expedition. The arch can be visited and inside it has two elevators that take you to the top to admire the beautiful view. The most famous attraction of Saint Louis is the Jefferson Expansion Memorial (11 N 4th St.) that houses the Gateway Arch, a true and just symbol of the city. During our route we will also discover one of the most important natural attractions in the state, the Meramec Caverns. Even the battles of the Civil War have left evidence of their passage and you will find many historical sites and museums dedicated to those events. history, the state of Missouri has been famous for being the starting point for expeditions to the West including the well-known Overland, Oregon and Santa Fe Trails, and the Lewis and Clark Expedition. Where to Stay Along Route 66 in Missouri.